An efficient aldol-type direct reaction of isatins with TMSCH2CN.
نویسندگان
چکیده
Cesium fluoride catalyzed direct cyanomethylation of various isatins by using trimethylsilyl acetonitrile (TMSAN) as a nucleophile has been developed. The reaction has been explored for a number of isatins, with various substitutions on its aromatic ring. Further, the versatility of the reaction is demonstrated by converting the direct aldol adducts to the corresponding intermediates of natural products and medicinally important compounds.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 38 شماره
صفحات -
تاریخ انتشار 2015